The San Francisco Giants (19-11) and the San Diego Padres (18-11) wrap up a 2-game series Wednesday. First pitch from Petco Park is at 4:10 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Preview the April 30 matchup between the San Francisco Giants and San Diego Padres with odds over/under, game spread, betting lines and more.

Pregame analysis and predictions of the San Francisco Giants vs. San Diego Padres MLB game to be played on April 30, 2025 on ESPN.

Bogaerts' seventh-inning, two-run homer helped the Padres to a 7-4 win over the Giants and ended an unwanted individual streak.

Xander Bogaerts homered and knocked in three runs as the San Diego Padres snapped a four-game losing streak with a 7-4 win over the visiting San Francisco Giants on Tuesday.

Xander Bogaerts went 2 for 4 with three RBIs, Nick Pivetta struck out nine in 5 1/3 innings and the San Diego Padres beat the San Francisco Giants 7-4 on Tuesday night. It was San Diego’s most runs since scoring 10 against the Chicago Cubs on April 14.