Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular ...

Corporatization” of health care, a process predicted decades ago, now refers to the general trend throughout the industry toward higher levels of integrated control by consolidated profit-seeking ...

Musunuru and colleagues 1 describe in the Journal an innovative approach in which gene editing is applied in the treatment of a very rare disease, the severe urea-cycle disorder carbamoyl ...

The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...

A 63-year-old woman was evaluated for dyspnea and edema. Soft-tissue thickening was noted in the retroperitoneum and mediastinum and around the heart and vessels. A diagnosis was made.

Explore a collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.

Chronic meningitis is broadly characterized as infectious or noninfectious (Table 1). Geographic region of residence, travel, immune status, and underlying illnesses are the initial building ...

Retinoblastoma is a childhood retinal cancer that occurs in approximately 6 of 100,000 live births, with 250 to 300 new cases per year in the United States and approximately 8000 worldwide. 1 ...

In the emergency department, the patient described the pain as sharp and rated it at 8 on a scale of 0 to 10 (with 10 indicating the most severe pain). The pain was worst in the epigastrium and in ...

Most rotator-cuff tears are degenerative, atraumatic, and more prevalent with age. Nonoperative treatment, including physical therapy, is typically recommended; surgery is considered in some cases.

Patients with severe asthma are at increased risk for a decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may be required to reduce the disease burden. This ...