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As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

In a June 12 conference at UW-Madison, researchers gathered from across the U.S. and abroad to discuss the latest progress on TDP-43 biomarkers. In all, 74 people attended in person, and 727 virtually ...

NULISA assays measure AD biomarkers in blood as accurately as do gold-standard assays. A panel of 123 CNS proteins could aid differential diagnosis. It may also sharpen prognosis and profile a ...

Anatomy explorers have charted a new path myeloid cells use to access the brain. On 3 June in Neuron, scientists led by Lindsay Hohsfield and Kim Green, both at the University of California, Irvine, ...

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's.

CagA disrupts bacterial biofilms. It also prevents Aβ and α-synuclein from forming fibrils. Scientists will test CagA in AD and PD mouse models to assess its therapeutic potential. Scientists estimate ...

Up-and-coming Alzheimer’s blood tests may soon be used for people with Down’s syndrome. In a longitudinal biomarker study of adults with three copies of ...

In mice, exercise spurred neurogenesis in wild-type and APP/PS1 mice. The workouts induced protective gene-expression signatures across cell types in the dentate gyrus. Exercise reversed some of the ...

Since February, the termination of some 2,482 grants worth $8.6 billion has shaken the scientific community, including AD researchers. Thanks to government databases and intrepid scientists tracking ...

Tau hyperphosphorylation and conformational changes in the brain parenchyma start around seven months. Tangle-like pathology is mainly observed in the brain stem and spinal cord, and to a lesser ...