Indianapolis police report a fatal crash at East 30th and North Shadeland Avenue, resulting in at least one death. The incident is ongoing.

US President Donald Trump and Ukrainian President Volodymyr Zelensky engage in a private meeting during the funeral of Pope ...

Massive explosion and fire at Iran's Shahid Rajaei port suspected to be related to a shipment of chemical used to make ...

People with diseases caused by rare mutations have fewer options and poorer prospects than other patients despite rapid ...

INDIANAPOLIS (WISH) — The 2025 NFL Draft is underway. See who will be the newest members of the Indianapolis Colts. Warren ...

INDIANAPOLIS (WISH) — Pacers Sports & Entertainment will host the inaugural Rebound for Re-Entry 3 v 3 Basketball Tournament ...

Joella's Hot Chicken offers a special deal for Derby Week with 25% off Chicken Tender Hot Boxes and Feed the Flock catering ...

The third round of talks between Iran and the United States over Tehran’s rapidly advancing nuclear program have ended.

An AP-NORC poll finds many Americans don't agree with President Trump’s aggressive efforts to quickly enact his agenda.

Free Parvo vaccinations and microchipping offered on May 10 at Vet Tech Institute of Indiana to prevent deadly disease among ...

Shedeur Sanders’ wait finally has ended. The Cleveland Browns selected the Colorado quarterback and son of Hall of Famer ...

Indianapolis ranks among the most air polluted cities in the U.S., according to a report by the American Lung Association.