A 77-year-old woman presented with a 2-day history of abdominal pain, nausea, and vomiting. CT of the abdomen revealed herniation of a loop of ileum that was inferior to the inguinal ligament and ...

Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular ...

The study of retinoblastoma has led to fundamental insights into carcinogenesis, cell-cycle regulation, the genetic basis of cancer, and tumor-suppressor genes, as well as to advances in therapy.

Simplified regimens for the treatment of human immunodeficiency virus type 1 (HIV-1) infection may increase patient satisfaction and facilitate adherence. In this phase 3, open-label, multicenter, ...

Hairy-cell leukemia, a rare B-cell cancer driven by a BRAF mutation and manifesting with cytopenias and splenomegaly, is responsive to purine analogue chemotherapy and to BRAF inhibitors combined w ...

Ibrutinib, a Bruton’s tyrosine kinase inhibitor, may have clinical benefit when administered in combination with bendamustine and rituximab and followed by rituximab maintenance therapy in older ...

The authors examine the epidemiology, pathogenesis, clinical expression, and differential diagnosis of Behçet’s syndrome, as well as targeted therapeutics.

Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular dise ...

Most rotator-cuff tears are degenerative, atraumatic, and more prevalent with age. Nonoperative treatment, including physical therapy, is typically recommended; surgery is considered in some cases.

The clinical aspects and implications of hearing loss in adults are presented, along with the current criteria for cochlear implantation. Modern cochlear-implant surgery and its pros and cons are d ...

We describe a case of life-threatening disseminated coccidioidomycosis in a previously healthy child. Like most patients with disseminated coccidioidomycosis, this child had no genomic evidence of ...

Over the past two decades, the incidence of syphilis has increased sharply. The courses of both untreated and treated disease can be unpredictable. This review presents guidance on clinical recogni ...