Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular ...

Retinoblastoma is a childhood retinal cancer that occurs in approximately 6 of 100,000 live births, with 250 to 300 new cases per year in the United States and approximately 8000 worldwide. 1 ...

Treatment was initiated in 308 participants per group. At week 48, HIV-1 RNA levels of 50 copies per milliliter or higher were found in 5 participants (1.6%) receiving long-acting therapy and in 3 ...

Hairy-cell leukemia, a rare B-cell cancer driven by a BRAF mutation and manifesting with cytopenias and splenomegaly, is responsive to purine analogue chemotherapy and to BRAF inhibitors combined w ...

Ibrutinib, a Bruton’s tyrosine kinase inhibitor, may have clinical benefit when administered in combination with bendamustine and rituximab and followed by rituximab maintenance therapy in older ...

The authors examine the epidemiology, pathogenesis, clinical expression, and differential diagnosis of Behçet’s syndrome, as well as targeted therapeutics.

The lifetime risk of cardiovascular disease was 24% (95% confidence interval [CI], 21 to 30) among women and 38% (95% CI, 30 to 45) among men for whom all five risk factors were present. In the ...

Most rotator-cuff tears are degenerative, atraumatic, and more prevalent with age. Nonoperative treatment, including physical therapy, is typically recommended; surgery is considered in some cases.

The clinical aspects and implications of hearing loss in adults are presented, along with the current criteria for cochlear implantation. Modern cochlear-implant surgery and its pros and cons are d ...

Disease outcomes in coccidioidomycosis depend on cellular immunity, but the precise elements of that response have not been fully characterized. Resolution of infection is associated with robust ...

Syphilis was first recognized in Europe in the late 15th century 1; its cause, Treponema pallidum subspecies pallidum, was identified four centuries later. The advent of penicillin, together with ...

Cerebral venous thrombosis is an unusual cerebrovascular disorder that is of current interest, in part because of rare cases associated with certain of the coronavirus disease 2019 (Covid-19 ...