再生医学中组织和细胞治疗的一个主要问题是来自不相容个体的移植物的免疫排斥。 成熟的卵子含有对患者细胞核重新编程所必需的因子，从而能够建立与患者相容的多能干细胞，用于治疗多种退行性疾病。

心肌细胞（CM）是不可再生的。 自我更新的多能人类胚胎干细胞 (hESC) 可以分化为用于细胞疗法的 CM。 在成人CM中，Ca(2+)诱导的Ca(2+)通过兰尼碱受体(RyR)从肌浆网(SR)释放是兴奋-收缩耦合的关键。 因此，hESC 衍生的 CM 需要具有 ...

心肌细胞（CM）是不可再生的。 自我更新的多能人类胚胎干细胞 (hESC) 可以分化为用于细胞疗法的 CM。 我们最近报道，Ca(2+) 处理对于 hESC 衍生的 CM (hESC-CM) 的兴奋-收缩耦合至关重要，具有功能性但不成熟。 胞质Ca(2+)瞬时幅度 ...

该项目增强了干细胞的可及性、可扩展性和协作性。它提供了特征化的 hpsc 系、crispr 编辑和自动化平台上的分化，从而加速了生物学、疾病研究和再生医学的进展。

未标记：垂直袖状胃切除术（VSG）是临床最常进行的减肥手术之一，用于缓解肥胖和糖尿病。 然而，VSG 发挥其有益作用的精确分子机制仍然难以捉摸。 我们报道膜结合 G 蛋白偶联胆汁酸受体 GPBAR-1（也称为 TGR5）是介导小鼠 VSG ...

The mission of the California Institute for Regenerative Medicine (CIRM) is to accelerate world class science to deliver transformative regenerative medicine treatments in an equitable manner to a ...

Members of the public are invited to attend CIRM governing board meetings and to provide comment on agenda items. On this page we list agendas for all public meetings, including meetings of the ...

CIRM funds stem cell research to institutions throughout California. On the map below, click on any marker to learn more about our funding to that institution. You can explore the awards they’ve ...

Foundation – Discovery Stage Research Projects Qiong Annabel Wang Utilizing Age-Specific Adipocyte Progenitor Cells for Cell Therapy in Older Patients $1,508,997 Clinical Trial Stage Projects Prof.

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At the California Institute for Regenerative Medicine (CIRM), we are committed to the continued funding of groundbreaking research in regenerative medicine. To reflect this commitment, we are ...

For most awards, carry forward is allowable without prior approval. For Training awards (EDUC2, EDUC3, EDUC4, and EDUC5), obligated trainee funds, program administration and associated IDC carry ...